6 Some patients also complain of nausea, heartburn (although this is not the predominant complaint) and even weight loss (few patients with functional dyspepsia are obese). 3- 5įunctional dyspepsia refers to troublesome upper gastrointestinal symptoms including inability to finish a meal (early satiety), postprandial fullness, and epigastric pain or burning. 1, 2 It affects 10% of the population and is more prevalent in women. These include reassurance, dietary modification, acid suppression, prokinetic drugs including fundic relaxors, tricyclic antidepressants, rifaximin and psychological therapy.įunctional dyspepsia is a common problem in Australia and often impacts on quality of life and work productivity. There are many treatment options available, with varying levels of evidence of efficacy. While functional dyspepsia is distressing and affects quality of life, it has no long-term impacts on mortality. Slow gastric emptying occurs in 20% of cases. It is thought to be associated with upper gastrointestinal inflammation and motility disturbances, which may be triggered by an infectious or allergenic agent, or a change in the intestinal microbiome. The pathophysiology of functional dyspepsia is not completely understood. The presence of red flags, such as weight loss or anaemia, should prompt investigation including gastroscopy. It can easily be overlooked as the symptoms overlap with gastro-oesophageal reflux disease and irritable bowel syndrome.ĭiagnosis is clinical, however it requires exclusion of structural gastrointestinal disease. Functional dyspepsia is characterised by troublesome early satiety, fullness, or epigastric pain or burning.
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